• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer
  • Alcohol Addiction
    • Alcohol Addiction
    • Alcohol Detox
    • Alcohol Rehab
    • Alcoholism, Addiction And Recovery
    • Alcohol Withdrawal Symptoms
    • Get Help For Alcohol Addiction
    • Alcohol & Alcoholism
    • Stop Drinking Alcohol
    • Alcohol Detox At Home
    • Counselling For Alcohol Addiction
    • Alcohol Drinks Journal
    • Alcohol Units Guide
  • Drug Addiction
    • Drug Addiction
      • Drug Detox
      • Drug Rehab
    • Cocaine Addiction
      • Cocaine Detox
      • Cocaine Rehab
    • Cannabis Addiction
      • Cannabis Detox
      • Cannabis Rehab
    • Heroin Addiction
      • Heroin Detox
      • Heroin Rehab
    • Amphetamine Addiction
    • Crack Addiction
    • Crystal Meth Addiction
    • GHB Addiction
    • Ketamine Addiction
    • Mephedrone Addiction
    • Prescription Drug Addiction
    • Steroid Addiction
  • Helping Others
    • Help For My Addicted Husband
    • Help For My Wife
    • Help For My Son
    • Help For A Loved One
    • Help For My Daughter
    • Help For A Work Colleague
    • Help For A Friend
    • Help For Myself
  • Locations
  • Prescription Drugs
    • Prescription Drug Rehab
    • Prescription Drug Detox
    • Pregabalin Addiction
    • Hydrocodone Addiction
    • Oxycodone Addiction
    • Benzodiazepine Addiction
    • Fentanyl Addiction
    • Valium Addiction
  • Online Rehab
  • Blog
  • Contact Us
Help 4 Addiction Logo

Help 4 Addiction

Drug & Alcohol Rehabilitation

Trustpilot

Call Us: 0203 955 7700

Get Rehab Prices Start Your Consultation
  • Alcohol Addiction
        • Alcohol Addiction
        • Alcohol Detox
        • Alcohol Rehab
        • Alcoholism, Addiction And Recovery
        • Get Help For Alcohol Addiction
        • Alcohol & Alcoholism
        • Alcohol Withdrawal Symptoms
        • Stop Drinking Alcohol
        • Alcohol Detox At Home
        • Counselling For Alcohol Addiction
        • Alcohol Drinks Journal
        • Alcohol Units Guide
  • Drug Addiction
        • Drug Addiction
          • Drug Detox
          • Drug Rehab
        • Cocaine Addiction
          • Cocaine Detox
          • Cocaine Rehab
        • Cannabis Addiction
          • Cannabis Detox
          • Cannabis Rehab
        • Heroin Addiction
          • Heroin Detox
          • Heroin Rehab
        • Amphetamine Addiction
        • Crack Addiction
        • Crystal Meth Addiction
        • GHB Addiction
        • Ketamine Addiction
        • Mephedrone Addiction
        • Steroid Addiction
        • Prescription Drug Addiction
  • Helping Others
        • Help For My Addicted Husband
        • Help For My Wife
        • Help For A Friend
        • Help For My Son
        • Help For My Daughter
        • Help For A Work Colleague
        • Help For A Loved One
        • Help For Myself
  • Locations
  • Prescription Drugs
        • Prescription Drug Rehab
        • Prescription Drug Detox
        • Benzodiazepine Addiction
        • Fentanyl Addiction
        • Oxycodone Addiction
        • Hydrocodone Addiction
        • Pregabalin Addiction
        • Valium Addiction
  • Online Rehab
  • Blog
  • Contact Us

Esketamine Nasal Spray Is A Newly Approved Solution for Treatment-Resistant Depression

21st March 2019 by Dipesh

Last updated on April 29th, 2022 at 01:59 pm

Anxiety and depression disorders are the most common mental illnesses in the US. They are affecting over 40 million adults with the age of 18 and older every year.  Despite the fact that anxiety disorders are highly treatable, less than half of those suffering receive treatment. Specialists suggest that depression and anxiety could develop from a complex set of risk factors. Genetics, brain chemistry, personality, and unfortunate life events can all trigger depression to occur. The prevalence of depressive episodes was higher among adult females compared to males. There are several differences in the manner in which the depressed moods manifest based on age and sex. Depression in men usually manifests in tiredness, irritability, and anger. On the other hand, specialists have noticed that women’s depressed moods evolve in sadness, worthlessness, and guilt.

 

Treatment-Resistant Depression

The most popular theory that aims to explain the development of depression in individuals is based on the fact that it may be caused by low brain levels such as neurotransmitters. Serotonin and norepinephrine are the neurotransmitters which are associated by the brain with the feelings of happiness and wellbeing. Yet, recent studies show that the neurotransmitters may not be the only cause of it. This suggested specialists that antidepressants which aim to increase serotonin and norepinephrine levels may not be a treatment that works for every individual suffering from depression. As traditional antidepressants only affect neurotransmitters, it may be the reason why some patients do not respond positively to them.

Treatment-resistant depression is a challenge to the field of clinical psychiatry.  Almost half of the individuals who suffer from major depressive disorder experience treatment resistance.  It is often linked with suicidal ideation and suicide attempts. The current antidepressant treatments play an invaluable role as they fail to relieve the symptoms of depression. Those individuals struggling with major depressive disorder which is treatment resistant do not respond to treatments. This condition makes them battle with persistent feelings of sadness, sleep disturbances, low energy, and, eventually, deep thoughts of death and suicide.

Specialists cannot provide exact data to explain why some individuals experience treatment-resistant disorder and others do not. However, they have observed that women and senior citizens are struggling with TRD at higher rates. The reasons behind the vulnerability to antidepressant treatments can stand behind biological and psychological factors, as well as the overall health which can also play a major role in it.

 

Rapidly-Acting Treatments

The National Institute of Mental Health has funded a research project which promotes the development of quicker and innovative therapies for treatment-resistant depression. Specialists have noticed that current existing antidepressant medications usually take up to a few weeks to reduce the symptoms of depression and suicidality in patients. Moreover, some patients suffer from major depressive disorder which does not fully responds to the existing treatments. Trouble is that severe depression can become life-threatening if not treated. Usually, the patients who suffer from it start developing suicidal thoughts which resulted in several suicidal attempts.  Recent studies show worrying results that estimate that over 50 percent of individuals in the US who die by suicide suffer from major depression. Although the best way to prevent suicide is the early detection and treatment of depression, some patients diagnosed with depression do not respond positively to the current existing treatments.

The urgent need for faster and more efficient antidepressant treatment has made researchers consider ketamine as a viable solution for individuals who suffer from treatment-resistant major depressive disorder. The drug has been proved to have a significant positive effect in reducing the symptoms of depression within hours.

 

What Is Esketamine?

Ketamine is a drug which has hallucinogenic effects and is used illegally. It is a short-acting drug which induces euphoria, sustained pain relief, and sedation mixed with powerful hallucinogenic effects. Yet, although ketamine and esketamine are perceived to be practically the same thing, they work differently especially due to the way they are administered. Both ketamine and esketamine aim to bump up levels of feel-good brain chemicals called serotonin. Yet, esketamine targets glutamate which is a neurotransmitter that sends messages across the brain.  Various clinical trials have proven that esketamine is up to ten times more effective than any current antidepressant treatment currently existing.

The side-effects of Spravato nasal spray

Before approval, the intranasal esketamine was tested several times and has proved to be generally well tolerated. Yet, due to the risk of various adverse outcomes and the potential abuse or misuse of the drug, the newly approved esketamine nasal spray is only available through a restricted distribution.  There are a few common side-effects experienced by the patients who were part of the controlled clinical trials and treated with Spravato. The most common side-effects were including disassociation, dizziness, vomiting, nausea, lethargy, and increased blood pressure. All patients were constantly monitored during the clinical trials and the treatment with the esketamine nasal spray were either interrupted or reduced depending on the side-effects experienced by the patients. Yet, the long-term safety study conducted by the specialists has shown that Spravato nasal spray was generally well tolerated by the patients.

Although electroconvulsive therapy (ECT) was proven to be a faster acting antidepressant method, it comes with several risks of cognitive side-effects. That is why researchers have made significant efforts to discover a better solution to help individuals struggling with treatment-resistant depression. After a long-standing need for additional and more efficient treatments for treatment-resistant depression, The U.S Food and Drug Administration has approved Spravato, the esketamine nasal spray. FDA has conducted several controlled clinical trials to determine the efficacy and safety of this drug. Due to safety concerns, the drug will only be available through a restricted distribution system as it must be administrated in a certified medical environment where the patient can be monitored. Yet, it is a promising solution for patients who were struggling with major depressive disorder episodes.

The newly approved esketamine intranasal spray has rapid effects on reducing the symptoms of major depressive disorder. Usually, within 24 to 48 hours, the symptoms of depression are reduced in patients. These rapid effects of Spravato are a promising solution for helping patients at high risk of committing suicide or self-harm.

If you or a loved one is suffering from any form of addition or depression then take the first step and seek help, call us on 0203 955 7700 where one of our experts can point you in the right direction.

Filed Under: Latest News, Rehab Tagged With: Recovery, rehab

Sharing is Caring

About Dipesh

Information here about the Author - Pellentesque ac metus et lectus ultricies ultrices eget lobortis arcu. Praesent eleifend vitae dui et molestie. Lorem ipsum dolor sit amet, consectetur adipiscing elit.

Primary Sidebar

  • FREE CALLBACK SERVICE

    We offer a free
    callback service 24/7

    Simply enter your number below
    and our addiction counsellors will call
    you back in a few minutes.

  • This field is for validation purposes and should be left unchanged.

Related Articles

Things to Consider Before Choosing a Rehab Clinic in London

15th June 2022 By Nicholas Conn Leave a Comment

Steroid Abuse: Know the Signs

8th June 2022 By Nicholas Conn Leave a Comment

Have you Taken a Tramadol Overdose?

30th May 2022 By Nicholas Conn Leave a Comment

Am I Enabling My Addicted Loved One?

20th May 2022 By Nicholas Conn Leave a Comment

5 Ways to Tackle a Family Member with Addiction

13th May 2022 By Nicholas Conn Leave a Comment

Tags

Adderall addiction Alcohol Alcohol Allergy Alcohol Poisoning Alcohol Poisoning Treatment Brighton child addict cocaine Codeine coun detox Devon - Paignton Drug addiction drugs dry january England Essex - Brentwood family festive Halloween Hertford home detox Kent - Goudhurst ketamine librium London Magic Mushrooms meth Naloxone online rehab Pancreatitis party drugs porn Recovery rehab relapse self-care Sheffield signs staying sober Stoke On Trent teenagers tramadol xanax

Footer

Get Help Now

  • Phone 0203 955 7700 or enter your phone number and get a call back.

    FREE CALL BACK SERVICE 24/7

  • This field is for validation purposes and should be left unchanged.

About Help 4 Addiction

Help 4 Addiction’s experienced support team are always on hand to offer you the most personal and cost effective options available for alcohol and drug addiction treatment

0203 955 7700
support@help4addiction.co.uk

Additional Links

  • Private Residential Rehab Clinics
  • Alcohol Addiction
  • Alcohol Rehab & Addiction Treatment
  • Alcohol Withdrawal Symptoms
  • Online Therapy
  • Detox from Home

Get Help Now

  • Phone 0203 955 7700 or enter your phone number and get a call back.

    FREE CALL BACK SERVICE 24/7

  • This field is for validation purposes and should be left unchanged.

© 2022 Help 4 Addiction. All Rights Reserved.

  • Privacy
  • Terms & Conditions
We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. By clicking “Accept All”, you consent to the use of ALL the cookies. However, you may visit "Cookie Settings" to provide a controlled consent.
Cookie SettingsAccept All
Manage consent

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. We also use third-party cookies that help us analyze and understand how you use this website. These cookies will be stored in your browser only with your consent. You also have the option to opt-out of these cookies. But opting out of some of these cookies may affect your browsing experience.
Necessary
Always Enabled
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Non-necessary
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.
SAVE & ACCEPT